About us

The Research Informatics Core (RIC), located in the Molecular Biology Research Building at the University of Illinois-Chicago (UIC), provides a broad spectrum of bioinformatics services to the UIC and Chicago-area research communities, including genomics, transcriptomics, epigenomics, metagenomics, metabolomics, and proteomics analysis, as well as applications in statistical analysis, systems biology, and machine learning.

To request a consultation, please fill out a service request form at RRC CrossLabs: go.uic.edu/ric (you will need to sign in).

To inquire about bioinformatics services, please contact us.

RIC events annoucement list

To subscribe to our events annoucement email list (RIC_events@uic.edu) please send an email to listserv@uic.edu with the following content. Please set the text "your_firstname" and "your_lastname" to YOUR firstname and lastname.

subscribe RIC_EVENTS your_firstname your_lastname

Additional instructions are available at https://help.uillinois.edu/TDClient/37/uic/KB/ArticleDet?ID=549.

Example results

The end result of these bioinformatics services is to provide investigators basic information concerning the abundance of taxa present in the samples sequenced using a targeted amplicon, e.g. 16S or ITS. The basic bioinformatic analysis includes basic processing of raw sequence data including read merging, adapter & quality trimming, chimeric checking and processing using DADA2 to generate a table of abundance data and associated taxonomic annotations.

NOTE: Differential analysis of the data are a separate service not included with basic processing of the data.

Basic processing (Cellranger) of 10X gene expression
Basic processing (Cellranger) of 10X gene expression and immune profiling data
Analyses of processed data.
NOTE: Analysis of the data are a separate service not included with basic processing of the data.

Long-read/Hybrid assembly

De novo genome assembly using both long read, i.e. PacBIO or Nanopore data, and short-read (Illumina) data.

Short-read assembly

De novo genome assembly using only short-read (Illumina) data.

Read based annotation

Pipeline generates taxonomic and functional gene annotations for each sequenced read and then generates counts summaries for the annotations.

Metagenomic assembly

Contigs are assembled, de novo from the sequence data. The resulting contigs are annotated taxonomically and putative gene features, i.e. open reading frames, are detected and annotated. Quantitative insights (read counts) are generated by aligning the sequence data for each sample to the assembled metagenome and then computing number of reads aligned to the contigs as well as the detected gene features.

Pipline produces a quantitated feature table with putative annotations

Tools

Hamming distance calculator